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Gastroenterology


WE HAVE THE HEART TO FOCUS ON THE GUT

Arena Pharmaceuticals takes an “all in” approach to developing our investigational gastrointestinal drugs.
Mechanism of Disease
  • ABOUT ULCERATIVE COLITIS

    Ulcerative colitis (UC) is a chronic disease where the innermost lining of the large intestine becomes inflamed and ulcers may form on the surface, which can cause symptoms such as frequent bowel movements, diarrhea, and bloody stools.

  • ABOUT CROHN’S DISEASE

    Crohn’s disease (CD) is a chronic inflammatory condition of the GI tract. Symptoms vary, but typically include persistent diarrhea, rectal bleeding, urgent need to move bowels, abdominal cramps and pain, constipation, fever, loss of appetite, weight loss, fatigue, and night sweats. In more severe cases, CD can lead to tears (fissures) in the lining of the anus, which may cause severe pain and bleeding. Inflammation may also cause a fistula to develop, which can be very serious and requires immediate medical attention.

  • ABOUT IRRITABLE BOWEL SYNDROME

    Irritable bowel syndrome (IBS) is a common disorder of the GI tract. Signs and symptoms include cramping, abdominal pain, bloating, gas, and predominant constipation (IBS-C) or diarrhea (IBS-D), or mixed (IBS-M). IBS is a chronic condition that needs to be managed long term. There are approximately 18 million patients1 in the United States with IBS, with approximately 80%2 reporting frequently recurring or continuous abdominal pain.

  • ABOUT EOSINOPHILIC ESOPHAGITIS

    Eosinophilic esophagitis (EoE) is a chronic immune disease in which eosinophils build up in the esophagus. The build-up of eosinophils can cause damage and inflammation leading to pain, trouble swallowing, and damage to the esophageal tissue.

REFERENCES: 1. Decision Resource Group IBS Epidemiology Mature Markets, March 2018. 2. Drossman DA, et al. J Clin Gastroenterol. 2009 Jul; 43(6): 541–550.